enter / eng /

Biological and Medical Sciences

BBMRI – Biological and BioMolecular resources Research Infrastructure


 Dr. Georges Dagher |  georges.dagher@inserm.fr  |


»European Research Infrastructure for BIONBANKS

Human biological samples including associated medical data and biomolecular re­search tools are key resources in unravelling the interplay of genetic and environ­mental factors causing diseases and impact on their outcome, identification of new targets for therapy and reduction of attrition in drug discovery and development.

BBMRI ERIC integrates 280 centers and 51 research institutions from 31 countries. It aims to set up a research infrastructure for biobanking and related fields. BBMRI will increase the scientific excellence and efficacy of Euro­pean research in the biomedical sciences as well as expand and secure competitiveness of European research and industry in a global context and attract pharmaceutical and biomedical research facilities.



BioMedBridges – Building data bridges between biological and medical infrastructures in Europe


 Mr Andrew Smith |  asmith@ebi.ac.uk

»BioMedBridges: Building Europe’s bio-medical data bridges

The ESFRI infrastructures in Biological and BioMedical Sciences face substantial challenges in accessing and sharing data and resources. The BioMedBridges con­sortium brings together the established ESFRI infrastructures with common goals of defining, implementing and delivering data interoperability across the biological and biomedical domains. From the setting of common standards and access rules, which will govern the sharing of sensitive data between coun­tries, to the need to preserve the data generated through these Research Infrastructures, the international di­mension is at the heart of BioMedBridges. The global life sciences community is vast, and the improvement that research in this domain makes to health, wellbeing and society around the world is pivotal. BioMedBridges will lay the foundation for data preservation from the key European Research Infrastructures. With open access to data of the highest quality, life sciences researchers throughout the world can reap the benefits.



EATRIS – EATRIS European Infrastructure for Translational Medicine



 Mr Anton Ussi |



»EATRIS – Shaping European Translational Research in Medicine

Tremendous progress has been made in biomedical research in genomics, proteo­mics and metabolomics, which has led to increasing insight into the molecular me­chanisms that drive diseases. Yet the output of disease prevention, diagnosis and treatment solutions remains low. To overcome this fate a number of European coun­tries have gathered to take new actions for improving the translation of fundamental research from the bench to routine clinical use at the bedside, and vice versa. EATRIS is a not-for-profit organization established to integrate basic and clinical research in dedicated European institutes of translational excellence organized around five pro­duct areas, namely Biomarkers, Molecular Imaging & Tracers, Advanced Therapy Medicinal Products, Vaccines and Small Molecules. Via a ‘One-Stop-Shop’ mechanism, EATRIS serves the needs of European academia and industry in translational medicine by providing access to cutting edge facilities and scientific experts, for top re­searchers with projects showing the highest potential for patient benefit.


ELIXIR – The Life Sciences Infrastructure for Biological Information


 Mr Andrew Smith

  asmith@ebi.ac.uk  


»ELIXIR: Enabling the Life Science Community to Solve Global Challenges

Such is the potential reach of ELIXIR that it is one of the few ESFRI Research Infra­structures considered to be of ’Global Significance’. Whilst ELIXIR begins as Europe’s Life Sciences Infrastructure for Biological Information, the benefits to researchers of having freely accessible biological data are truly global. ELIXIR will ensure that researchers throughout the world have access to the biological data needed to solve some of the most pressing Global Challenges, such as the health of the ageing population. Global Challenges require global solutions. These are issues of such complexity that no one Member State or continent can tackle alone. Likewise, the challenge of responding to the data deluge cannot be met in isolation. As ELIXIR begins to bring together leading institutes from around the world, so it will ensure that Member States avoid duplication of effort and that researchers glo­bally will have access to the most complete data available.





EMBRC – European Marine Biological Resource Centre


 Dr. Wiebe H.C.F. Kooistra



Marine organisms are becoming increasingly important both as biological models for researchers and as a source of innovative products and services for society. Their unique features can be translated, through R&D, into industrial applications and novel products. EMBRC will be a distributed research infrastructure consisting of leading marine biological stations across Europe. It will provide access to marine organisms at research and training facilities to end-users from academia, industry and policy makers. EMBRC is now in its preparatory phase. Additional marine institutes can join as aspiring partners and become full partners in the construction and operation phases if they fit the strategic plan for EMBRC and obtain the support from their member states. In addition, EMBRC explores collaborations with other RIs in the ERA and with similar organizati­ons and sister marine biological institutes in other countries.



EPPN – European Plant Phenotyping Network



 Prof. Dr. Ulrich Schurr



The ability to quantitatively analyze plant phenotypic traits and their response to the environment is an essential requirement for genetic and physiological research to enable application of scientific findings in bioeconomy. Today molecular technolo­gies allow the generation of large amount of data at a still decreasing cost. The un­derstanding of the link between genotype and phenotype has progressed slowly because of insufficient technical and conceptual capacity to probe existing genetic resources. Europe has become a key driver in defining innovative solutions for the development of infrastructures for plant phenotyping. The European Plant Phenotyping Network (EPPN) aims at creating synergies between the leading plant phenotyping institutions in Europe as a nucleus for the development of a strong European plant phenotyping community. EPPN will strengthen Europe’s leading role in plant phenotyping research and application by creating of a community of research institutes, universities, industry and SMEs.




EU-OPENSCREEN – European Infrastructure of Open Screening Plat­forms for Chemical Biology



 Dr. Ronald Frank |  office@eu-openscreen.eu  |


EU-OPENSCREEN, the European Infrastructure of Open Screening Platforms for Chemical Biology, aims to satisfy the needs for new bioactive compounds in all fields of the Life Sciences (e.g. human and veterinary medicine, systems biology, biotechnology, agriculture and nutrition). It will involve Europe’s leading compound screening sites open to external users and cover all technologies and resources required for the discovery of biologically active substances. The EU-OPENSCREEN facilities will be used by researchers from universities, re­search institutes and SMEs, who either have only limited in-house facilities or no access at all to such resources and expertise. EU-OPENSCREEN will help to increase knowledge of the bioactivities of chemical substances, as well as the responses of biological systems to challenge with these substances by collecting all generated data in a central database. EU-OPENSCREEN is currently in its early 2nd year of the Preparatory Phase.ESFRI ROADMAP 2008EU-OPENSCREEN



Euro-BioImaging – European Research Infrastructure for Imaging Tech­nologies in Biological and Biomedical Sciences


 Dr. Jan Ellenberg



»The ESFRI Biomedical Imaging Research Infrastructure Euro-BioImaging: Euro­pean and International Collaborations

Euro-BioImaging is a large-scale research infrastructure project on the ESFRI Ro­admap and will deploy a pan-European distributed biological and biomedical ima­ging infrastructure in a harmonized manner. The infrastructure will provide access to and training in cutting edge imaging technologies as well as resources for sharing image data. In a 3-year preparatory phase (2010-2013) Euro-BioImaging closely collaborates with national imaging communities and consults with imaging infrastruc­ture users and providers (pan-European survey, proof-of-concept studies) in order to define eligibility criteria for future infrastructure nodes. An international External Advisory Board (USA, Australia) regularly advises Euro-BioImaging in technological and strategic matters. International collaborations and practical workshops with the Australian Microscopy & Microanalysis Research Facility are ongoing and enable the exchange of information and sharing of best practice.




EVA – European Virus Archive


 Prof. Jean-Louis Romette



The concept of EVA is unique. There is no equivalent virus collection; neither does any other collection provide the accessibility, reagent backup, sequence data, prove­nance, quality control, and capacity to inform, through the web. The EVA consortium is dedicated to the provision of unique collections of high quality and authenticated virus strains through it’s virtual bio-resource centre, for fundamental and applied research.The nine core partners of the EVA consortium have merged their specialised collections to create a catalogue advertising these viruses through a web portal. The attractiveness of the project has raised the interest of of Global Health Agencies like WHO and CDC’s and of other institutions, currently,13 of them have integrated the EVA Consortium as associated partners. EVA is in the third year of its existence under Framework Programme 7. The ultimate objective of EVA is to make it a permanent archive that can provide access to viruses and reagents globally. This will be achieved through extension of the funding arrangements and also through expansion of the range of contributors to the collection.



Infrafrontier – The European research infrastructure for phenotyping and archiving of model mammalian genomes


 Dr. Michael Raess

 michael.raess@helmholtz-muenchen.de


Medically related life sciences use mouse models to understand the functional basis of human disease. The European mouse clinics provide a systemic view on human disease by undertaking a comprehensive functional and molecular characterization of mammalian gene function. EMMA – the European Mouse Mutant Archive preserves mouse models and distri­butes them to the biomedical research community. These world-leading facilities provide a strong research base for Europe and play an important role in international activities such as the International Mouse Phenotyping Consortium (IMPC) and the International Federation of Mouse Resources (FIMRe). However, the existing capacities do not match the increasing demand by the community. Moreover, sustainable funding solutions are not always in place. These problems are being addressed by the ESFRI project Infrafrontier. Infrafrontier shapes the European Research Area by providing a sustainably funded pan-European research infrastructure for systemic phenotyping, archiving and distribution of mouse models and by coordinating its international activities.



Instruct – Instruct Integrating Biology



 Prof. David Ian Stuart



»Instruct enables researchers to pool resources for an integrated view of cell structure

To study the components and interactions of a cell, spanning broad spatial (atomic to macromolecular) and temporal resolutions, scientists need many sophisticated technologies that no one laboratory can afford. Instruct makes access to structu­ral biology technologies more systematic and where unavailable through national centres, uncouples it from the need for formal collaborations with those providing the instrumentation. Instruct coordinates 22 centres providing access and expertise through a single on-line application, greatly empowering the use of an integrated experimental approach to solving fundamental scientific questions. By liaising with other European infrastructure, coordination and training programmes, Instruct will provide significant opportunities to expose researchers to new technologies and new creative approaches. Instruct launched formally on 23rd Fe­bruary 2012 and the first access proposal is approved and in process, signifying the official opening of Instruct for business.



WeNMR – A Worldwide e-Infrastructure for NMR and structural biology


 Dr. Alexandre Bonvin



»WeNMR: bringing Grid computing to a worldwide structural biology community

WeNMR brings together research teams in Structural Biology into a Virtual Research Community (VRC). The WeNMR platform integrates and streamlines the computatio­nal approaches necessary for NMR and SAXS data analysis and structural modelling making use of a grid-based e-Infrastructure fully integrated into EGI. Web portals provide user-friendly access to the grid, shielding end users from the complexity of the grid. WeNMR has grown to become the largest VRC in life sciences, accounting for more than 30% of CPU usage. WeNMR is linked to IN­STRUCT in line with the ESFRI roadmap, but also aims at serving all relevant worldwide communities. Nowadays more than 20% of the users come from outside Europe, covering both North and Latin America, Africa and Asia Pacific. WeNMR is tightly interacting with the EGI, various European projects and with the US Open Science Grid in order to facilitate and support its operation and continuing expansion.

Developed in MCG
2011, Bogolyubov Institute for Theorethical Physics